Elevated Tricuspid Regurgitant Jet Velocity In Lebanese Patients With Sickle Cell Disease Is Associated With Severe Disease and Is Clustered In Families

Autor: Abdennour, Rouba, Arabi, Mariam, Nietert, Paul, Keyrouz, Sarah, Khoury, Ruby, Saab, Raya, Muwakkit, Samar A., El Abiad, Jad, El Majzoub, Nadim, Dabbous, Ibrahim A., Bitar, Fadi, Abboud, Miguel R.
Zdroj: Blood; November 2013, Vol. 122 Issue: 21 p4684-4684, 1p
Abstrakt: Pulmonary hypertension (PHT) is a known complication of sickle cell disease (SCD), and it is indirectly assessed by measurement of the tricuspid regurgitant jet velocity (TRV). Despite the fact that PHT was found to be associated with early mortality in adults SCD patients, the association between elevated TRV and SCD severity and mortality is still controversial particularly in children and adolescents. The objective of this study was to investigate the relationship between elevated TRV and parameters of disease severity in children, adolescents and young adults with SCD.
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