| Autor: |
Biron, K K, Noblin, J E, de Miranda, P, Elion, G B |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; January 1982, Vol. 21 Issue: 1 p44-50, 7p |
| Abstrakt: |
The uptake, distribution, and anabolism of the nucleoside analog 9-(2-hydroxyethoxymethyl) guanine (acyclovir) were compared in herpes simplex virus-infected and uninfected mice. Analyses of tissue distribution and the concentration of acyclovir after either a single dose or multiple doses failed to reveal significant differences between drug levels in infected and uninfected animals. Extracts of tissues from [8-14C] acyclovir-treated animals were examined by high-performance liquid chromatography to detect the presence of any phosphorylated forms of the drug. The sensitivity of this method did not allow a reproducible demonstration of acyclovir anabolism in herpes simplex virus-infected tissues owing to the low numbers of infected cells per organ. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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