| Autor: |
McRipley, R. J., Whitney, R. R. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; July 1976, Vol. 10 Issue: 1 p38-44, 7p |
| Abstrakt: |
Reproducible experimental surgical-wound infections in mice for use in the evaluation of topical antibacterial agents are described. The experimental would was created on the backs of mice by means of a midline incision and was infected by means of cotton sutures monocontaminated with Staphylococcus aureusor Pseudomonas aeruginosa. The course of these wound infections was followed by quantitation of surface bacteria through use of a surface rinse technique. Surface wound counts of the infecting organisms thus obtained appeared to reflect the dynamics of the total wound count, as determined by homogenization of biopsied tissue. Treatment of infected wounds with a placebo cream had only a slight effect on surface wound counts and on mortality in the case of the S. aureusinfection but enhanced markedly the lethality of the P. aeruginosainfection. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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