| Autor: |
Allen, Lois B., Huffman, John H., Revankar, Ganapathi R., Tolman, Robert L., Simon, Lionel N., Robins, Roland K., Sidwell, Robert W. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; October 1975, Vol. 8 Issue: 4 p474-478, 5p |
| Abstrakt: |
Equine abortion virus (EAV)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. These experiments demonstrate that 9-β-d-arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of ∼60. Ara-HxMP prevented hepatitis-associated deaths in hamsters, reduced the titer of EAV developing in hamsters, and inhibited the increase of serum glutamic pyruvic transaminase in EAV-infected hamsters. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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