BL-S 640, a Cephalosporin with a Broad Spectrum of Antibacterial Activity: Properties In Vitro

Autor: Leitner, F., Buck, R. E., Misiek, M., Pursiano, T. A., Price, K. E.
Zdroj: Antimicrobial Agents and Chemotherapy; March 1975, Vol. 7 Issue: 3 p298-305, 8p
Abstrakt: BL-S 640 was evaluated in vitro by comparison with cephalothin, cephaloridine, cefazolin, and cephalexin. The new compound was more active than the control cephalosporins against most major gram-negative and some gram-positive species. Moreover, its antibacterial spectrum included strains of Enterobacter, Proteus morganii, P. rettgeri, and Providencia stuartii, species generally resistant to the other cephalosporins. BL-S 640 was an effective bactericidal agent for strains of various species of Enterobacteriaceae. In human plasma, the compound was 58% protein bound.
Databáze: Supplemental Index