| Autor: |
Swarnkar, Supriya, Avchalumov, Yosef, Espadas, Isabel, Grinman, Eddie, Liu, Xin-an, Raveendra, Bindu L., Zucca, Aya, Mediouni, Sonia, Sadhu, Abhishek, Valente, Susana, Page, Damon, Miller, Kyle, Puthanveettil, Sathyanarayanan V. |
| Zdroj: |
Cell Reports; July 2021, Vol. 36 Issue: 2 |
| Abstrakt: |
Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive. Here, we explore the roles of KIF5C and KIF3A, two members of kinesin superfamily of molecular motors (Kifs), and find that loss of function of either kinesin decreases dendritic arborization and spine density whereas gain of function of KIF5Cenhances it. KIF5Cfunction is a rate-determining component of local translation and is associated with ∼650 RNAs, including EIF3G, a regulator of translation initiation, and plasticity-associated RNAs. Loss of function of KIF5Cin dorsal hippocampal CA1 neurons constrains both spatial and contextual fear memory, whereas gain of function specifically enhances spatial memory and extinction of contextual fear. KIF5C-mediated long-distance transport of local translation substrates proves a key mechanism underlying structural plasticity and memory. |
| Databáze: |
Supplemental Index |
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