Effect of Racephenicol on Antibiotic Resistance of Lactose-Fermenting Enteric Bacteria in Chickens

Autor: Rollins, Larry D., Pocurull, Dorothy W., Reynolds, Steven
Zdroj: Antimicrobial Agents and Chemotherapy; September 1973, Vol. 4 Issue: 3 p277-280, 4p
Abstrakt: The incidence of lactose-fermenting enteric organisms resistant to chloramphenicol increased from less than 0.1% prior to treatment to more than 90% in two groups of chickens fed racephenicol-supplemented feed at 50 or 140 g/ton for 10 days, whereas controls remained unchanged. A concurrent increase in the incidence of organisms resistant to dihydrostreptomycin, oxytetracycline, ampicillin, and sulfonamides also occurred. Minimum inhibitory concentrations for chloramphenicol increased from <10 µg/ml to >300 µg/ml in most Escherichia coliisolates in response to treatment. The observed resistance was transferable to E. coliand Salmonella.
Databáze: Supplemental Index