| Autor: |
Waitz, J. A., Moss, E. L., Oden, E. M., Wagman, G. H., Weinstein, M. J. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; December 1972, Vol. 2 Issue: 6 p464-469, 6p |
| Abstrakt: |
Sch 14342 is an aminoglycoside antibiotic coproduced as a minor component in the gentamicin fermentation. Sch 14342 was found to have the same antibacterial spectrum as gentamicin in vitro and in vivo, and was approximately one-third as active in mouse protection tests. Sch 14342 relative to gentamicin was one-third as toxic in acute tests in mice, one-eighth as toxic in renal toxicity tests in dogs, and an estimated one-tenth as toxic in cat ataxia tests. Sch 14342 possesses a significantly improved therapeutic index relative to gentamicin with reference to ataxia potential and renal toxicity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
