Tilorone Hydrochloride: Lack of Correlation Between Interferon Induction and Viral Protection

Autor: Giron, David J., Schmidt, Jerome P., Pindak, Frank F.
Zdroj: Antimicrobial Agents and Chemotherapy; May 2021, Vol. 1 Issue: 1 p78-79, 2p
Abstrakt: The protection of mice against MM virus infection and the induction of circulating interferon by tilorone hydrochloride were determined. Whereas protection was evident with doses of 0.15 and 1.5 mg/kg, interferon was not detected with doses lower than 150 mg/kg. Protection was apparently not dependent on interferon induction.
Databáze: Supplemental Index