| Autor: |
Bernhard, Wörmann, Shashikant R., Mehta, Abby L., Maizel, Tucker W., LeBien |
| Zdroj: |
Blood; July 1987, Vol. 70 Issue: 1 p132-138, 7p |
| Abstrakt: |
Experiments were conducted to determine the effect of low mol wt B cell growth factor (L-BCGF) on B cell precursor acute lymphoblastic leukemia (ALL). L-BCGF induced a significant increase in 3H-TdR incorporation in 28 of 37 bone marrow aspirates from patients with B cell precursor ALL, with stimulation indices ranging from 2 to 129. Fluorescence-activated cell sorting confirmed that in five of seven patients the common acute lymphoblastic leukemia antigen (CALLA)/CD10 positive leukemic cells were responding directly to L-BCGF. L-BCGF was capable of inducing, in some patients, an increase in absolute viable cells and could also induce colony formation in vitro. The response of B cell precursor ALL was not attributable to β IL 1, IL 2, or 7 interferon. These results indicate that the majority of B cell precursor ALL undergo a proliferative response to L-BCGF, suggesting a regulatory role for this lymphokine in the growth of B cell precursors.© 1987 by Grune & Stratton, Inc. 0006-4971/87/7001-0016$3.00/0 |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
