Gene Deletion in a Patient With Chronic Granulomatous Disease and McLeod Syndrome: Fine Mapping of the Xk Gene Locus

Autor: Frey, Daniel, Machler, Marco, Seger, Reinhard, Schmid, Werner, Orkin, Stuart H.
Zdroj: Blood; January 1988, Vol. 71 Issue: 1 p252-255, 4p
Abstrakt: In a patient suffering from X-linked chronic granulomatous disease (X-CGD)—a disorder of phagocytesuperoxide gen-eration—and McLeod syndrome, characterized by the absence of the red cell Kell antigen, we identified a deletion of the entire X-CGD gene by means of DNA hybridization with a cDNA probe. Our findings suggest that the X-CGD and McLeod loci are physically close in the p21 region of the X chromosome proximal to the Duchenne muscular dystrophy locus.© 1988 by Grune & Stratton, Inc. 0006-4971/88/710l-0048$ 3.00/0
Databáze: Supplemental Index