| Autor: |
Bakkeren, J.A.J.M., de Vaan, G.A.M., Hillen, H.F.P. |
| Zdroj: |
Blood; May 1979, Vol. 53 Issue: 5 p883-891, 9p |
| Abstrakt: |
In children with acute lymphoblastic leukemia (ALL) the effect of prednisone therapy on the cell-cycle phase distribution of leukemic bone marrow cells was determined with pulse cytophotometry at the time of diagnosis. Also, the interrelationship with the presence of the sheep erythrocyte receptor as a marker for T cells was investigated. In 17 of 21 patients prednisone treatment caused a decrease in the percentage of cells in the S + G2+ M phases. In 11 of 12 adult patients with ALL the same result was obtained. In a group of 31 children with ALL, 6 cases of T-cell ALL occurred in combination with intermediate or high WBC counts. The 3 patients with the highest E-rosetting percentages had rather high proportions of bone marrow cells in the S + G2+ M phases. No correlation could be established between the WBC count or the E-rosetting percentage and the chance for complete remission. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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