| Autor: |
P. Heyns, Anthon du, Badenhorst, Philip N., Lotter, Mattheus G., Pieters, Henry, Wessels, Paula, F. Kotze, Harry |
| Zdroj: |
Blood; January 1986, Vol. 67 Issue: 1 p86-92, 7p |
| Abstrakt: |
Mean platelet survival and turnover were simultaneously determined with autologous 111ln-labeled platelets (nlln-AP) and homologous 61Cr-labeled platelets (51Cr-HP) in ten patients with chronic immune thrombocytopenic purpura (ITP). In vivo redistribution of the 111ln-AP was quantitated with a scintillation camera and computer-assisted image analysis. The patients were divided into two groups: those with splenic platelet sequestration (spleen-liver 111ln activity ratio >1.4), and those with diffuse sequestration in the reticuloendothelial system. The latter patients had more severe ITP reflected by pronounced thrombocytopenia, decreased platelet turnover, and prominent early hepatic platelet sequestration. Mean platelet life span estimated with B1Cr-HP was consistently shorter than that of 111ln-AP. Platelet turnover determined with 61Cr-HP was thus overestimated. The difference in results with the two isotope labels was apparently due to greater in vivo elution of 51 Cr. Although the limitations of the techniques should be taken into account, these findings indicate that platelet turnover is not always normal or increased in ITP, but is low in severe disease. We suggest that this may be ascribed to damage to megakaryocytes by antiplatelet antibody. The physical characteristics in 111ln clearly make this radionuclide superior to 51 Cr for the study of platelet kinetics in ITP. |
| Databáze: |
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| Externí odkaz: |
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