| Autor: |
Smith, Carl H., Schulman, Irving, Ando, Richard E., Stern, Gertrude |
| Zdroj: |
Blood; July 1955, Vol. 10 Issue: 7 p707-717, 11p |
| Abstrakt: |
The Effectiveness of transfusions in the correction of anemia in many types of disorders has been so striking that the possibilities of their depressant effect on blood formation are frequently overlooked. This side-effect, long recognized, was suspected as a causative factor in explaining one of the puzzling features in severe Mediterranean anemia, namely, that even with removal of the spleen, an anticipated rise in hemoglobin level is not obtained from a particular volume of blood. The release from an inhibitory influence was suggested in the preceding study1by the rise in fetal hemoglobin, a component strictly of endogenous origin, when transfusions were reduced in the post-splenectomy period. This aspect of transfusions in Mediterranean anemia was, therefore, deemed worthy of further investigation in order to elucidate still another mechanism involved in the maintenance of hematopoietic equilibrium in this and other chronic anemias. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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