| Autor: |
Marchisio, Pier Carlo, Bergui, Luciana, Corbascio, Guelfa C., Cremona, Ottavio, D'Urso, Nicolette, Schena, Marina, Tesio, Luisa, Caligaris-Cappio, Federico |
| Zdroj: |
Blood; August 1988, Vol. 72 Issue: 2 p830-833, 4p |
| Abstrakt: |
The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β2integrin (CD18) rings surround an F-actin core; (2) the β1integrin is localized within the F-actin core; (3) the β3integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence. © 1988 by Grune & Stratton, Inc. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
