| Autor: |
Geissler, Klaus, Valent, Peter, Bettelheim, Peter, Sillaber, Christian, Wagner, Brunhilde, Kyrle, Paul, Hinterberger, Wolfgang, Lechner, Klaus, Liehl, Ekke, Mayer, Peter |
| Zdroj: |
Blood; March 1992, Vol. 79 Issue: 5 p1155-1160, 6p |
| Abstrakt: |
Using a primate model, we examined the effect of recombinant human interleukin-3 (rhlL-3) and rhlL-6 on thrombopoiesis in vivo. Administration of 33 μg/kg/d of rhIL-3 for 11 to 14 days increased levels of circulating colony-forming units megakaryocyte (CFU-Mk) by approximately 15-fold in five rhesus monkeys without raising their platelet counts. In contrast, administration of 30 μg/kg/d of rhIL-6 for 10 days in four animals did not increase CFU-Mk levels but significantly raised platelet counts from a mean pretreatment value of 460 x 103/μL (range 360 to 610) to a mean maximum of 746 x 103/μL (665 to 790) on day 8. If monkeys were pretreated with rhIL-3 (33 or 100 pg/kg/d for 11 days) to expand their CFU-Mk compartment, the thrombopoietic effect of rhIL-6 was synergistically enhanced leading to platelet counts above 1,000 x 103/μL (mean maximum value 1,247) in all three primates studied. The sequential administration of rhIL-3 and rhIL-6 might represent a powerful strategy to stimulate thrombopoiesis in vivo. |
| Databáze: |
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