| Autor: |
Croudace, Joanne E., Inman, Charlotte F., Abbotts, Ben. E., Nagra, Sandeep, Nunnick, Jane, Mahendra, Prem, Craddock, Charles, Malladi, Ram, Moss, Paul A.H. |
| Zdroj: |
Blood; November 2012, Vol. 120 Issue: 20 p4246-4255, 10p |
| Abstrakt: |
Chemokines regulate the migration of hemopoietic cells and play an important role in the pathogenesis of many immune-mediated diseases. Intradermal recruitment of CD8+T cells by CXCL10 is a central feature of the pathogenesis of cutaneous acute GVHD (aGVHD), but very little is known about the pathogenesis of chronic GVHD (cGVHD). Serum concentrations of the 3 CXCR3-binding chemokines, CXCL9, CXCL10, and CXCL11, were found to be markedly increased in patients with active cGVHD of the skin (n = 8). An 80% decrease in CD4+cells expressing CXCR3 was seen in the blood of these patients (n = 5), whereas CD4+cells were increased in tissue biopsies and were clustered around the central arterioles of the dermis. The well-documented increase in expression of CXCL10 in aGVHD therefore diversifies in cGVHD to include additional members of the CXCR3-binding family and leads to preferential recruitment of CD4+T cells. These observations reveal a central role for chemokine-mediated recruitment of CXCR3+T cells in cGVHD. |
| Databáze: |
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