| Autor: |
Acevedo, Gilbert, Branchford, Brian R., Brzezinski, Christine, Sather, Susan, Brodsky, Gary, DeRyckere, Deborah, Zhang, Weihe, Liu, Jing, Earp, H. Shelton, Wang, Xiaodong, Frye, Stephen V, Graham, Douglas K., Di Paola, Jorge |
| Zdroj: |
Blood; November 2013, Vol. 122 Issue: 21 p2296-2296, 1p |
| Abstrakt: |
Growth Arrest Specific gene 6 (Gas6) is a ligand for the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases found on the surface of platelets. Previous studies have shown that stimulation of these receptors results in amplification of platelet activation and thrombus stabilization via activation of phosphatidylinositol-3-kinase (PI3K) and Akt, leading to phosphorylation of the β3 integrin. Previous work (from our lab and others) demonstrated that inhibition of the Gas6/TAM pathway results in impaired platelet aggregation, reduced aggregate stability, and decreased platelet spreading. Additionally, knockout mice deficient in the receptor or ligand are protected from venous and arterial thrombosis, but retain normal tail bleeding times. Here, we describe development and characterization of novel Mer-selective small molecule inhibitors (SMIs) for thrombosis applications. |
| Databáze: |
Supplemental Index |
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