| Autor: |
Sjamsoedin-Visser, Liesbeth J.M., Heijnen, Cobi J., Zegers, Ben J.M., Stoop, Jan W. |
| Zdroj: |
Blood; November 1988, Vol. 72 Issue: 5 p1474-1477, 4p |
| Abstrakt: |
In human immune deficiency virus (HlV)-seroposrtive hemophilia patients, a low number of CD4+ lymphocytes is found, as well as a low CD4+/CD8+ ratio. In previous studies, it has been shown that antigen-specific T-helper cell (CD4+) function was present and no excessive antigen-specific T-suppressor cell (CD8+) function could be demonstrated. In this report, we studied another activity of CD4+ cells, namely the capacity to induce T-suppressor cell activity. The results clearly show a selective dysfunction of CD4+ suppressor-inducer (Tsi) cell function. Since these HIV-seropositive hemophilia patients showed the presence of activated B cells in the peripheral circulation refractory to antigen-specific T-helper cell signals and secreting specific antibodies spontaneously, we raised the hypothesis that the activated B cells in the patients activate the Tsi cells in vivo. This constant activation leads to a functional exhaustion of the Tsi cell pool. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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