| Autor: |
Dianzani, Umberto, Pileri, Alessandro, Boccadoro, Mario, Palumbo, Antonio, Pioppo, Paola, Bianchi, Alberto, Camponi, Alessandro, Fossati, Giorgio, Battaglio, Silvano, Massaia, Massimo |
| Zdroj: |
Blood; September 1988, Vol. 72 Issue: 3 p1064-1068, 5p |
| Abstrakt: |
The phenotypic pattern of peripheral blood T (PBT) lymphocytes was correlated with diagnosis and clinical status in 63 patients with monoclonal gammopathies (MGs). The numbers of lymphocytes expressing activation and CD11 determinants were significantly increased in suppressor/ cytotoxic and helper/inducer subpopulations of patients with multiple myeloma (MM) and MG of undetermined significance (MGUS). The number of activated suppressor/ cytotoxic cells was closely correlated with diagnosis and disease status. These cells were significantly higher in MM at diagnosis (160 ± 88) than MGUS patients (61 ± 79; P < .01). Their number decreased to MGUS levels in MM in stable remission (58 ± 53), but not in MM with tumor progression (172 ± 102; P < .001). In individual patients, part of these cells specifically adhered to dishes precoated with the related M-protein. No monoclonal T-beta gene rearrangement was detected in PBT and cytotoxic/ suppressor subpopulations from two patients with a large proportion of activated cells.1988 by Grune & Stratton, Inc.0006-4971/88/7203-0044$3.00/0 |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
