Rapid Prenatal Diagnosis of β Thalassemia Using DNA Amplification and Nonradioactive Probes

Autor: Cai, S.-P., Chang, C.A., Zhang, J.-Z., Saiki, R.K., Erlich, H.A., Kan, Y.W.
Zdroj: Blood; February 1989, Vol. 73 Issue: 2 p372-374, 3p
Abstrakt: We used in vitro DNA amplification by the polymerase chain reaction and nonradioactive probes for prenatal diagnosis of β thalassemia in Chinese from the Guangdong province. Exact molecular diagnoses were made in all 20 fetuses studied over a 6-month period. We conclude that this method of prenatal diagnosis for β thalassemia is a viable approach in many parts of the world where this disease is common.
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