Histochemical Demonstration of Terminal Deoxynucleotidyl Transferase in Leukemia

Autor: Hecht, Thomas, Forman, Stephen J., Winkler, Ursula S., Santos, Sally, Winkler, Karl J., Carlson, Fumiko, Maslow, William C., Borer, William Z., Blume, Karl G.
Zdroj: Blood; October 1981, Vol. 58 Issue: 4 p856-858, 3p
Abstrakt: White blood cells from 22 patients with leukemia and lymphoma were studied for the presence of terminal deoxynucleotidyl transferase with a peroxidase-antiperoxidase method. The enzyme was detected in leukemic cells of 5 patients with acute lymphoblastic leukemia and 1 patient with chronic myelogenous leukemia, whereas 16 patients with different forms of leukemia or lymphoma were negative for this enzyme. Comparative studies using a biochemical and an indirect immunofluorescence assay revealed complete concordance between these three methods.
Databáze: Supplemental Index