| Autor: |
Barrett, A. John, Horowitz, Mary M., Ash, Robert C., Atkinson, Kerry, Gale, Robert Peter, Goldman, John M., Henslee-Downey, P. Jean, Herzig, Roger H., Speck, Bruno, Zwaan, Ferry E., Bortin, Mortimer M. |
| Zdroj: |
Blood; June 1992, Vol. 79 Issue: 11 p3067-3070, 4p |
| Abstrakt: |
Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) has a poor prognosis when treated with conventional chemotherapy. We analyzed the outcome of 67 HLA-identical sibling bone marrow transplants (BMTs) for Ph1-positive ALL reported to the International Bone Marrow Transplant Registry (IBMTR). Twenty-one of 67 (31%) transplant recipients survived in continuous complete remission more than 2 years after transplant. Two-year actuarial proba-bilities (95% confidence interval) of leukemia-free survival were 38% (23% to 55%) for 33 patients transplanted in first remission, 41% (23% to 61%) for 22 patients transplanted after relapse, and 25% (9% to 53%) for 12 patients failing to achieve remission with conventional chemotherapy. These data indicate that transplants are effective treatment for PM-positive ALL. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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