| Autor: |
van Hensbergen, Yvette, de Boer, Helen, Slot, Manon C., Schipper, Laurus F., Brand, Anneke, Fibbe, Willem E. |
| Zdroj: |
Blood; November 2005, Vol. 106 Issue: 11 p1267-1267, 1p |
| Abstrakt: |
Aim:Delayed platelet reconstitution in the peripheral blood (PB) remains a problem in transplantation with umbilical cord blood (CB)-derived stem cells. Previously, we have shown that transplantation with ex-vivo expanded CB CD34+cells (CD34exp) with thrombopoietin for 10 days, results in an accelerated platelet reconstitution in NOD/SCID mice. It has been shown that mesenchymal stem cells (MSC) are able to enhance the overall engraftment when co-transplanted with CB CD34+cells. Therefore, we investigated whether co-transplantation of MSC with CD34+cells or CD34expcells may have an additive effect in shortening the time to platelet recovery and on the total number of platelets in the PB at 6 weeks after transplantation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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