High Frequency of HPA-1Bin Leukemia Patients.

Autor: Novaretti, Marcia C.Z., Bonifacio, Silvia L., Ruiz, Azulamara S., Fontes, Lia V.Q., Dorlhiac-Llacer, Pedro E., Chamone, Dalton A.F.
Zdroj: Blood; November 2007, Vol. 110 Issue: 11 p4028-4028, 1p
Abstrakt: Background: The HPA-1 alloantigen is a biallelic co-dominant system on human platelets carried on glycoprotein IIIa. Alloimmunization against the HPA-1 has clinical relevance in multiple transfused patients, in neonates with alloimmune thrombocytopenia and in platelet refractoriness. Accurate HPAgenotyping is important to facilitate the provision of HPA-matched blood components for these patients. The purpose of this study was to determine the HPA-1gene frequencies in apheresis blood donors and in leukemia patients.
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