| Autor: |
Tsui, Sze Pui, Alvin, Ip HW, Zhang, Chunxiao, Tang, Tommy W.F., Lin, CH, Cheung, Arthur, Cheng, Grace, So, Jason Chi Chiu, Leung, S.Y., Au, Tommy CH, Ma, Edmond S.K., Chan, Chris T.L., Ng, Margaret, Cheng, Kelvin CK, Wong, Kit Fai, Siu, Lisa L.P., Yip, Sze Fai, Lin, S.Y., Lau, Szeman June, Luk, T.H., Lee, Harold K K, Lau, Chi Kuen, Kho, Bonnie, Kwong, Yok Lam, Javed, Asif, Leung, Anskar Yu Hung |
| Zdroj: |
Blood; November 2019, Vol. 134 Issue: 1, Number 1 Supplement 1 p1400-1400, 1p |
| Abstrakt: |
Background. Cytogenetically normal acute myeloid leukaemia (CN-AML) occurs in 50% adult AML and is a group of diseases with diverse mutations and distinct clinical outcome. CEBPα, NPM1and FLT3mutations that are commonly seen in CN-AML have been incorporated into risk stratification. However, prognostic impacts of other gene mutations and their combinations in this AML subtype have remained unclear. In this study, we examined a cohort of young adults with de novo CN-AML who have received uniform treatment protocol in Hong Kong and identified a mutation pentad that might define their clinical outcome. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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