| Autor: |
Nervi, Bruno, Rettig, Michael, Ritchey, Julie, Walker, Jon, Bauer, Gerhard, Herrbrich, Philip, Bonyhadi, Mark L., Nolta, Jan A., DiPersio, John F. |
| Zdroj: |
Blood; November 2004, Vol. 104 Issue: 11 p4979-4979, 1p |
| Abstrakt: |
Graft-versus-host disease (GvHD) remains a major cause of morbidity and mortality following allogeneic stem cell transplantation. One approach to preserve the beneficial graft-versus-leukemia while minimizing GvHD is to genetically modify donor T cells with a herpes simplex virus thymidine kinase (HSV-tk) suicide gene that can selectively phosphorylate the prodrug ganciclovir (GCV) resulting in T cell suicide should GvHD develop. We recently developed a new chimeric suicide gene by fusing HSV-tk to the extracellular and transmembrane domains of human CD34 (ΔCD34-tk; Mol. Ther. 2003; 8:29–41). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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