| Autor: |
Fujino, Takeshi, Goyama, Susumu, Sugiura, Yuki, Inoue, Daichi, Yamasaki, Satoshi, Matsumoto, Akiko, Sato, Naru, Morinaga, Hironobu, Shikata, Shiori, Fukuyama, Tomofusa, Tanaka, Yosuke, Asada, Shuhei, Fukushima, Tsuyoshi, Honda, Hiroaki, Nishimura, Emi K, Shibata, Tatsuhiro, Suematsu, Makoto, Kitamura, Toshio |
| Zdroj: |
Blood; November 2019, Vol. 134 Issue: 1, Number 1 Supplement 1 p821-821, 1p |
| Abstrakt: |
Somatic mutations of the ASXL1gene are recurrently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations causes CH are not understood. Here, using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we investigated the effect of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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