| Autor: |
Proctor, Diana M., Dangana, Thelma, Sexton, D. Joseph, Fukuda, Christine, Yelin, Rachel D., Stanley, Mary, Bell, Pamela B., Baskaran, Sangeetha, Deming, Clay, Chen, Qiong, Conlan, Sean, Park, Morgan, Welsh, Rory M., Vallabhaneni, Snigdha, Chiller, Tom, Forsberg, Kaitlin, Black, Stephanie R., Pacilli, Massimo, Kong, Heidi H., Lin, Michael Y., Schoeny, Michael E., Litvintseva, Anastasia P., Segre, Julia A., Hayden, Mary K. |
| Zdroj: |
Nature Medicine; 20210101, Issue: Preprints p1-9, 9p |
| Abstrakt: |
Candida aurisis a fungal pathogen of high concern due to its ability to cause healthcare-associated infections and outbreaks, its resistance to antimicrobials and disinfectants and its persistence on human skin and in the inanimate environment. To inform surveillance and future mitigation strategies, we defined the extent of skin colonization and explored the microbiome associated with C. auriscolonization. We collected swab specimens and clinical data at three times points between January and April 2019 from 57 residents (up to ten body sites each) of a ventilator-capable skilled nursing facility with endemic C. aurisand routine chlorhexidine gluconate (CHG) bathing. Integrating microbial-genomic and epidemiologic data revealed occult C. auriscolonization of multiple body sites not targeted commonly for screening. High concentrations of CHG were associated with suppression of C. aurisgrowth but not with deleterious perturbation of commensal microbes. Modeling human mycobiome dynamics provided insight into underlying alterations to the skin fungal community as a possible modifiable risk factor for acquisition and persistence of C. auris. Failure to detect the extensive, disparate niches of C. auriscolonization may reduce the effectiveness of infection-prevention measures that target colonized residents, highlighting the importance of universal strategies to reduce C. auristransmission. |
| Databáze: |
Supplemental Index |
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