| Autor: |
Le, Phong, Mai Thu, Si Nguyen, Stoldt, Volker R., Vo, Toi Van, Scharf, Rudiger E., Huynh, Khon |
| Zdroj: |
Blood; December 2017, Vol. 130 Issue: 1, Number 1 Supplement 1 p2307-2307, 1p |
| Abstrakt: |
Introduction:Insoluble fibrils are the active form of fibronectin (FN) with exposed functional domains capable of interacting with a variety of biomolecules and cells to support many cellular processes. Recent studies show that the formation of FN fibrils can occur in cell-free systems. Currently, the characteristic of FN fibrils and their potential in wound healing application are not fully understood. Our project aims at (i) using urea to induce the formation of FN fibrils with different conformations and (ii) to characterize their conformation-dependent effect on cellular adhesion and spreading. |
| Databáze: |
Supplemental Index |
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