| Autor: |
Evano, G., Schaus, J. V., Panek, J. S. |
| Zdroj: |
Organic Letters; February 2004, Vol. 6 Issue: 4 p525-528, 4p |
| Abstrakt: |
The asymmetric synthesis of the fully elaborated macrocyclic core of cytotrienins A−D, potent apoptosis-inducing agents, is described. Synthetic highlights include the construction of the aniline bond using a copper-mediated amidation and the use of a ring-closing metathesis (RCM) reaction to efficiently install the (E,E,E)-triene and simultaneously construct the macrocyclic lactam. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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