LPL and ADAM-29Gene Expressions Stratify Prognosis in Clinical Stage BinetA and B Chronic Lymphocytic Leukemia Patients

Autor: Barreto, Wolney Góis, Belluzzi, Lorenza Oliveira, Siufi, Grazziella Curado, de Andrade Silva, Marçal Cavalcante, Kimura, Eliza Yuriko Sugano, Vasconcelos, Yuri, Arce, Inara Lucia, Yamamoto, Mihoko
Zdroj: Blood; November 2008, Vol. 112 Issue: 11 p4177-4177, 1p
Abstrakt: Introduction: Chronic Lymphocytic Leukemia (CLL) is the most frequent adult leukemia in western countries. It is known to have a heterogeneous clinical course, some patients presenting an indolent disease while others have an aggressive disease requiring prompt treatment. Therefore, an individualized approach, especially in early clinical stage patients is necessary. Recent studies suggest that the biological markers LPLand ADAM-29could be useful to predict prognosis in CLL patients: LPLbeing associated with an unfavorable prognosis while ADAM-29to favorable one.
Databáze: Supplemental Index