| Autor: |
Moorman, Anthony V, Konn, Zoe J, Barber, Kerry E, Wright, Sarah L, Stewart, Adam RM, Parker, Helen, Richards, Sue M, Kinsey, Sally E, Eden, Osborn B, Vora, Ajay J, Mitchell, Christopher D, Strefford, Jonathan C, Harrison, Christine J |
| Zdroj: |
Blood; November 2008, Vol. 112 Issue: 11 p430-430, 1p |
| Abstrakt: |
Approximately 20–25% of children with B-cell precursor ALL harbour the t(12;21) (p13;q22)/ETV6-RUNX1fusion which has been associated, almost universally, with a favourable outcome. However, as some ETV6-RUNX1patients relapse additional predictors of treatment failure are required. Although additional abnormalities involving 12p and 21q (AA) are known to occur in these patients, previous studies have produced conflicting results with respect to their prognostic impact. In order to investigate the prognostic relevance of AA in this subset of patients, we screened a large cohort of children by FISH with break-apart probes targeting the ETV6(DakoCytomation, Denmark) and RUNX1loci (centromeric - RP11-272A03 and telomeric - RP11-396G11, Sanger Institute, UK). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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