| Autor: |
Aitken, John M., Phan, Khoi, Bodman, Samantha E., Sharma, Sowmya, Watt, Anthony, George, Peter M., Agrawal, Gaurav, Tie, Andrew B.M. |
| Zdroj: |
Pathology; December 2021, Vol. 53 Issue: 7 p818-823, 6p |
| Abstrakt: |
In ruminants Mycobacterium aviumsubspecies paratuberculosis(MAP) is the causative organism of a chronic granulomatous inflammatory bowel disease called Johne's disease (JD). Some researchers have hypothesised that MAP is also associated with Crohn's disease (CD), an inflammatory bowel disease in humans that shares some histological features of JD. Despite numerous attempts to demonstrate causality by researchers, direct microbiological evidence of MAP involvement in CD remains elusive. Importantly, it has not been possible to reliably and reproducibly demonstrate mycobacteria in the tissue of CD patients. Past attempts to visualise mycobacteria in tissue may have been hampered by the use of stains optimised for Mycobacterium tuberculosiscomplex (MTB) and the lack of reliable bacteriological culture media for both non-tuberculous mycobacteria (NTM) and cell-wall-deficient mycobacteria (CWDM). |
| Databáze: |
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