Microwave-Assisted Paal−Knorr Reaction. A Rapid Approach to Substituted Pyrroles and Furans

Autor: Minetto, G., Raveglia, L. F., Taddei, M.
Zdroj: Organic Letters; February 2004, Vol. 6 Issue: 3 p389-392, 4p
Abstrakt: An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a β-ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal−Knorr procedure carried out under microwave irradiation.
Databáze: Supplemental Index