New Insight into Vitamins E and K1as Anti-Quorum-Sensing Agents against Pseudomonas aeruginosa

Autor: Soltani, Sadaf, Fazly Bazzaz, Bibi Sedigheh, Hadizadeh, Farzin, Roodbari, Fatemeh, Soheili, Vahid
Zdroj: Antimicrobial Agents and Chemotherapy; 2021, Vol. 65 Issue: 6 pe01342-20-e01342-20, 200132879p
Abstrakt: Today, antivirulence compounds that attenuate bacterial pathogenicity and have no interference with bacterial viability or growth are introduced as the next generation of antibacterial agents. However, the development of such compounds that can be used by humans is restricted by various factors, including the need for extensive economic investments, the inability of many molecules to penetrate the membrane of Gram-negative bacteria, and unfavorable pharmacological properties and cytotoxicity.
Databáze: Supplemental Index