Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales

Autor: Zalacain, Magdalena, Lozano, Clarisse, Llanos, Agustina, Sprynski, Nicolas, Valmont, Thomas, De Piano, Cyntia, Davies, David, Leiris, Simon, Sable, Carole, Ledoux, Adeline, Morrissey, Ian, Lemonnier, Marc, Everett, Martin
Zdroj: Antimicrobial Agents and Chemotherapy; 2021, Vol. 65 Issue: 6 pe00203-21-e00203-21, 210020119p
Abstrakt: The global dissemination of metallo-β-lactamase (MBL)-producing carbapenem-resistant Enterobacterales(CRE) is a serious public health concern. Specifically, NDM (New Delhi MBL) has been a major cause of carbapenem therapy failures in recent years, particularly as effective treatments for serine-β-lactamase (SBL)-producing Enterobacteralesare now commercially available.
Databáze: Supplemental Index