| Autor: |
Golubickaite, Ieva, Ugenskiene, Rasa, Korobeinikova, Erika, Gudaitiene, Jurgita, Vaitiekus, Domas, Poskiene, Lina, Juozaityte, Elona |
| Zdroj: |
Biomarkers; May 2021, Vol. 26 Issue: 4 p343-353, 11p |
| Abstrakt: |
AbstractPurposeBreast cancer is the most frequent female cancer, leading to relapse with distant metastasis of approximately one-third of patients. Cancer is usually considered a genetic disease involving mutations in nuclear DNA. However, genes, coding for mitochondrial proteins or regulatory molecules, are rarely under consideration. This study aimed to analyse 10 single nucleotide variants in POLGand TFAMgenes and assess their association with tumour phenotype and disease outcome.Materials and methodsA total of 234 breast cancer patients were included in this study. Variations were determined with Real-Time PCR using TaqMan®probes.ResultsWe found that patients with POLGrs2307441 TT and CT genotypes had a lower probability for vascular invasion than those with CC genotype (p = 0.001). Patients with POLGrs2072267 AG genotype were predisposed for progression compared with GG genotype (p = 0.015). TFAMrs3900887 TT genotype was associated with a higher probability for positive oestrogen receptors (p = 0.003) and lymphatic invasion (p = 0.001) in comparison to AA genotype, patients with TT (p = 0.000) were more likely to have positive lymph nodes.ConclusionsOur data suggest that variations in POLGand TFAMgenes are important determinacies of tumour phenotype and disease outcome in breast cancer patients. |
| Databáze: |
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