Sepsis due to linezolid resistant Staphylococcus cohniiand Staphylococcus kloosii: First reports of linezolid resistance in coagulase negative staphylococci from India

Autor: Peer, MA, Nasir, RA, Kakru, DK, Fomda, BA, Bashir, G, Sheikh, IA
Zdroj: Indian Journal of Medical Microbiology; January-March 2011, Vol. 29 Issue: 1 p60-62, 3p
Abstrakt: Linezolid, a viable alternative to vancomycin against methicillin resistant staphylococcal isolates, has been in use for a decade around the globe. However, resistance against staphylococci remains extremely rare and unreported from most of the Asian countries. Herein, we report two cases of linezolid resistant, coagulase negative staphylococcal sepsis for the first time from India. The first case was an 18-year-old burn patient, who, after a major graft surgery, landed in sepsis, and linezolid resistant Staphylococcus cohniiwith an minimum inhibitory concentration (MIC) of >256 μg/ml by both broth microdilution and Etest, was isolated from multiple blood cultures. The second patient was a 60-year-old male with an intracranial bleed and sepsis, from whose blood cultures, linezolid resistant Staphylococcus kloosiiwas repeatedly isolated. Linezolid MIC was >32 μg/ml by broth microdilution and >16 μg/ml by Etest.
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