| Autor: |
Parchmann, Stefanie, Mueller, Martin J. |
| Zdroj: |
Journal of Biological Chemistry; December 1998, Vol. 273 Issue: 49 p32650-32655, 6p |
| Abstrakt: |
The free radical oxidation of arachidonic acid is known to generate complex metabolites, termed isoprostanes, that share structural features of prostaglandins and exert potent receptor-mediated biological activities. In the present study, we show that α-linolenic acid can undergo a similar oxidation process, resulting in a series of isomeric dinor isoprostanes E1. E-ring dinor isoprostane formation from linolenate was found to be catalyzed by soybean lipoxygenase. The main enzymatic products were 13- and 9-hydroperoxylinolenate but in addition, two dinor isoprostane E1regioisomers were formed with a yield of 0.31%. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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