| Autor: |
Batzri, Shmuel, Selinger, Zvi, Schramm, Michael, Robinovitch, Murray R. |
| Zdroj: |
Journal of Biological Chemistry; January 1973, Vol. 248 Issue: 1 p361-368, 8p |
| Abstrakt: |
Epinephrine caused rapid release of intracellular K+by acting on an α-adrenergic receptor in rat parotid gland slices. Continuous measurement by a K+-selective electrode served as an assay for the α-adrenergic response. The reaction reached a plateau 3 to 5 min after epinephrine addition when 30 to 50% of the K+which had been in the slices was released. Isoproterenol, which is specific for β-adrenergic receptors and causes amylase secretion from the slices, did not induce K+release. The concentration of epinephrine which caused a half-maximal K+release was 15 µm, whereas the concentration which caused a half-maximal rate of amylase secretion in the same system was almost two orders of magnitude lower (0.2 µm). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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