| Abstrakt: |
In the lung, collagen is found associated with bronchi, with blood vessels, and with the alveolar interstitium; it is known to be fundamental in the maintenance of lung structure and function. Two collagen chains, α1and α2, can be extracted from rabbit lung homogenates; each chain has an approximate molecular weight of 100,000 and is composed of amino acids that are characteristic of collagen, but are not specific for lung. Lung slices incubated in vitrosynthesize α1and α2chains, as demonstrated by carboxymethylcellulose chromatography, by sodium dodecyl sulfate acrylamide gel electrophoresis, by acidic acrylamide gel electrophoresis, by sensitivity to collagenase, and by sensitivity to trichloroacetic acid at 90°. |
