Polyglutamyl Derivatives of Folate as Substrates and Inhibitors of Thymidylate Synthetase

Autor: Kisliuk, Roy L., Gaumont, Yvette, Baugh, Charles M.
Zdroj: Journal of Biological Chemistry; July 1974, Vol. 249 Issue: 13 p4100-4103, 4p
Abstrakt: (l)-Tetrahydropteroyltriglutamate and (l)-tetrahydropteroylhexaglutamate were prepared and tested as substrates for thymidylate synthetase (EC 2.1.1.6) (methylenetetrahydrofolate:deoxyuridylate C-methyltransferase) from Lactobacillus casei. Both tetrahydropteroylpolyglutamates were more effective substrates than (l)-tetrahydropteroylglutamate, enhancing the reaction rate 3-fold when compared at 10-5m.
Databáze: Supplemental Index