| Autor: |
Čižmáriková, R., Markuliak, M., Habala, L., Valentová, J., Bilková, A. |
| Zdroj: |
Acta Facultatis Pharmaceuticae Universitatis Comenianae; January 2021, Vol. 67 Issue: 2 p34-44, 11p |
| Abstrakt: |
A homologous series of (3-alkoxymethyl-4-hydroxyphenyl)propan-1-ones was prepared by the reaction of (3-chloromethyl-4-hydroxyphenyl)propan-1-ones with the corresponding alcohols (methanol – decan-1-ol, propan-2-ol, 2-methylpropan-1-ol, 3-methylbutan-1-ol, cyclopentanol, benzylalcohol) in the presence of sodium hydrogen carbonate. The composition of the synthesised compounds was elucidated by IR, UV and 1H-NMR and 13C-NMR spectra. Selected compounds were tested against human pathogens: gram-positive bacterium Staphylococcus aureus(CNCTC Mau 29/58), gram-negative bacterium Escherichia coli(CNCTC 377/79) and yeast Candida albicans(CCM 8186). Their antimicrobial activities were expressed as minimum inhibitory concentrations. Antioxidant activity was determined using DPPH and ABTS.+methods. It could be shown that both biological activities, antimicrobial and antioxidant, were lower in comparison with the (2RS)-bis [3-(4-acetyl-2-propoxymethyl)phenoxy-2-hydroxypropyl]isopropylammonium fumarate type of beta blockers. |
| Databáze: |
Supplemental Index |
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