| Autor: |
Sukanya, S.H., Venkatesh, Talavara, Kumar S, Ravi, Bodke, Yadav D. |
| Zdroj: |
Chemical Data Collections; June 2021, Vol. 33 Issue: 1 |
| Abstrakt: |
In this work, we report a facile synthesis of a series of substituted-4-hydroxy/methoxy benzylidene derivatives (3a-i) viaKnoevenagel condensation reaction of different active methylene compounds (1) with 4-hydroxy/methoxy benzaldehyde (2) under reflux condition in aq. EtOH using catalytic amount of TiO2NPs. The structures of all the obtained compounds were confirmed by analytical and spectroscopic methods and screened for their antioxidant and anti-tubercular activities. Antioxidant activity results revealed that, the compound 3ewith IC50value 105.48 µg/mL showed very effective DPPH scavenging activity and compound 3hwith IC50value 129.72 µg/mLexhibited most effective nitric oxide radical scavenging activity compared to the reference standard BHT and ascorbic acid respectively. From the results of anti-TB activity, compound 3bdisplayed a more sensitivity at 25 µg/mL. Furthermore, synthesized compounds were assessed for molecular docking studies on the target enzymes Human peroxiredoxin 5 and enoyl-ACP reductase and they were emerged has an active antioxidant and anti-TB agents with least binding energy -5.8 and -8.0 kJ mol−1respectively. |
| Databáze: |
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