| Autor: |
Pickering, Warren P, Baker, Frease E, Brown, Jeremy, Butler, Heather L, Govindji, Sheena, Parsons, Julie M, Pawluczyk, Izabella Z A, Walls, John, Bevington, Alan |
| Zdroj: |
Nephrology Dialysis Transplantation; August 2003, Vol. 18 Issue: 8 p1475-1484, 10p |
| Abstrakt: |
Increased protein degradation during metabolic acidosis contributes to muscle wasting in uraemia. Adrenalectomy experiments in severely acidotic rats (arterial pH approximately 7.15) have shown that this is prevented in the absence of glucocorticoid. It should therefore be possible to block such muscle wasting with glucocorticoid receptor antagonist 11beta-(4-dimethylaminophenyl)-17beta-hydroxy,-17a-(prop-1-ynyl)-estra-4,9-dien-3-one (RU38486). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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