Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 3:  Synthesis of Fragment C15-21

Autor: Mickel, S. J., Sedelmeier, G. H., Niederer, D., Schuerch, F., Koch, G., Kuesters, E., Daeffler, R., Osmani, A., Seeger-Weibel, M., Schmid, E., Hirni, A., Schaer, K., Gamboni, R., Bach, A., Chen, S., Chen, W., Geng, P., Jagoe, C. T., Kinder, F. R., Jr., Lee, G. T., McKenna, J., Ramsey, T. M., Repic, O., Rogers, L., Shieh, W.-C., Wang, R.-M., Waykole, L.
Zdroj: Organic Process Research & Development; January 2004, Vol. 8 Issue: 1 p107-112, 6p
Abstrakt: Smith's procedure of preparing fragment C15-21 (5) from common precursor 3 was optimized. The ease of plant operations made this six-step route successful for the production of several kilograms of this fragment with high purity.
Databáze: Supplemental Index