| Autor: |
Parker, J. S., Smith, N. A., Welham, M. J., Moss, W. O. |
| Zdroj: |
Organic Process Research & Development; January 2004, Vol. 8 Issue: 1 p45-50, 6p |
| Abstrakt: |
ZM374979 cyanoacid was prepared from ZD4974 cyanoester by a selective Grignard reaction followed by selective ester hydrolysis. On conversion of ZM374979 cyanoacid to ZM374979 free base, atropisomerism was observed, necessitating the development of a process for the selective crystallisation of a single atropisomer. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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