| Autor: |
Gomez Fernandez, Mario Andrés, Nascimento de Oliveira, Marllon, Zanetti, Andrea, Schwertz, Geoffrey, Cossy, Janine, Amara, Zacharias |
| Zdroj: |
Organic Letters; 20210101, Issue: Preprints |
| Abstrakt: |
A new access to artemisinin is reported based on a selective photochemical hydrothiolation of amorphadiene, a waste product of the industrial semisynthetic route. This study highlights the discovery of two distinctive activation pathways under solvent-free conditions or using a photocatalyst promoting H-abstraction. Subsequently, a chemoselective oxidation of the resulting photochemically generated thioether, followed by a Pummerer rearrangement, affords dihydroartemisinic aldehyde, a key intermediate in the synthesis of artemisinin. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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