| Autor: |
Yoshida, Jun, Mizuno, Masaaki, Fujii, Masazumi, Kajita, Yasukazu, Nakahara, Norimoto, Hatano, Manabu, Saito, Ryuta, Nobayashi, Misato, Wakabayashi, Toshihiko |
| Zdroj: |
Human Gene Therapy; January 01, 2004, Vol. 15 Issue: 1 p77-86, 10p |
| Abstrakt: |
Transfer of interferon β gene via cationic liposomes has been found to induce regression of experimental glioma. We performed a pilot clinical trial of safety and effectiveness of this interferon β gene therapy in five patients with malignant glioma (glioblastoma multiforme or anaplastic astrocytoma). Transgene expression and antitumor activity were detected in four patients. Two patients showed a partial response (>50% tumor reduction) and two others had stable disease 10 weeks after beginning therapy. One patient could not be evaluated because of previous treatment with γ-knife therapy. This study suggests the feasibility and safety of interferon β gene therapy, which may become an important treatment option for patients with malignant glioma. |
| Databáze: |
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